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Advagraf 5mg Capsule PR

Astellas Pharma Inc

Information updated 18 January 2026

Tacrolimus (5mg) 5000.00

Overview

Advagraf 5mg Capsule PR (Tacrolimus) is a prescription medication used to prevent organ rejection in individuals with a history of kidney transplant. It works by suppressing the immune system, which helps to prevent the body from attacking the transplanted kidney.

Uses

Advagraf 5mg Capsule PR is specifically designed for individuals who have undergone a kidney transplant. It is used to:

  • Prevent organ rejection
  • Reduce the risk of transplant failure
  • Improve the long-term survival of the transplanted kidney

Mechanism of Action

Advagraf 5mg Capsule PR contains tacrolimus, a calcineurin inhibitor that suppresses the immune system. By blocking the action of calcineurin, tacrolimus prevents the activation of T-lymphocytes, which are a type of immune cell responsible for attacking foreign substances, including transplanted organs.

Dosage

The recommended dosage for Advagraf 5mg Capsule PR is as follows:

  • Take one 5mg capsule once daily in the morning
  • Swallow the capsule whole with a glass of water
  • Do not crush or chew the capsule
  • Take the medication exactly as prescribed by your doctor

Side Effects

Advagraf 5mg Capsule PR can cause a range of side effects, including:

  • Nausea and vomiting
  • Diarrhea
  • Abdominal pain
  • Headache
  • Fatigue
  • Tremors
  • Changes in blood pressure
  • Increased risk of infections

In rare cases, Advagraf 5mg Capsule PR can cause more serious side effects, including:

  • Kidney damage
  • Liver damage
  • Increased risk of cancer
  • Neurological problems

If you experience any of these side effects, contact your doctor immediately.

Precautions

Before taking Advagraf 5mg Capsule PR, inform your doctor about any of the following:

  • Allergies to tacrolimus or other medications
  • History of kidney or liver disease
  • History of cancer
  • Pregnancy or breastfeeding
  • Taking other medications that interact with tacrolimus

Your doctor may need to adjust your dosage or monitor your condition more closely if you have any of these conditions.

FAQs

Q: What happens if I miss a dose of Advagraf 5mg Capsule PR?

A: If you miss a dose of Advagraf 5mg Capsule PR, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule.

Q: Can I take Advagraf 5mg Capsule PR with other medications?

A: Advagraf 5mg Capsule PR can interact with other medications, including blood thinners, antacids, and certain antibiotics. Inform your doctor about all the medications you are taking before starting Advagraf 5mg Capsule PR.

Q: What are the long-term effects of taking Advagraf 5mg Capsule PR?

A: The long-term effects of taking Advagraf 5mg Capsule PR are not fully understood. However, studies have shown that tacrolimus can increase the risk of cancer, kidney damage, and liver damage in some individuals. Your doctor will monitor your condition regularly to minimize these risks.

Uses

  • General Health

Side Effects

  • Consult Doctor

Have questions about Advagraf 5mg Capsule PR?

Talk to a verified specialist who can guide you on dosage, alternatives, and interactions.

Safety Advice

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pregnancy

Consult Doctor

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alcohol

Caution

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driving

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