Dolo D Tablet

Overview

Dolo D Tablet is a prescription medication manufactured by Mankind Pharma, combining two active ingredients: Domperidone (10mg) and Pantoprazole (40mg). This combination belongs to a class of drugs known as gastroprokinetic agents and proton pump inhibitors, respectively. The primary function of Dolo D Tablet is to provide relief from symptoms associated with acid reflux and peptic ulcers, while also offering pain relief and contributing to overall gastrointestinal health. By addressing these issues, Dolo D Tablet helps improve the quality of life for individuals suffering from digestive disorders.

Uses and Indications

Dolo D Tablet is specifically prescribed for the treatment of conditions such as gastroesophageal reflux disease (GERD), peptic ulcers, and dyspepsia. It is also used to alleviate symptoms of acid reflux, including heartburn and regurgitation. The combination of Domperidone and Pantoprazole in Dolo D Tablet works synergistically to enhance gastrointestinal motility and reduce stomach acid production, thereby providing relief from discomfort and facilitating the healing of the stomach lining. This medication is often prescribed when lifestyle modifications alone are not sufficient to manage symptoms, or when additional therapeutic intervention is necessary to prevent complications.

Mechanism of Action

The mechanism of action of Dolo D Tablet can be understood by looking at how its two components work:

• Domperidone acts as a gastroprokinetic agent. It works by blocking dopamine receptors in the gastrointestinal tract, which in turn enhances the motility of the upper gastrointestinal tract without affecting the motility of the lower gastrointestinal tract. This action helps in accelerating gastric emptying and reduces the symptoms of nausea and vomiting.
• Pantoprazole is a proton pump inhibitor (PPI) that decreases the amount of acid produced in the stomach. It works by irreversibly inhibiting the H+/K+ ATPase (proton pump) in the gastric parietal cells. By reducing gastric acid secretion, Pantoprazole creates a less acidic environment in the stomach, which helps in healing ulcers and reducing the symptoms of acid reflux.

Dosage and Administration

The typical dosage of Dolo D Tablet is one tablet per day, usually taken in the morning. It is recommended to take this medication with food to minimize potential gastrointestinal side effects. However, the exact dosage and timing may vary depending on the individual's condition and the doctor's prescription. It is crucial to follow the doctor's orders and the instructions provided with the medication to ensure safe and effective treatment. Additionally, patients should not stop taking Dolo D Tablet without consulting their doctor, as sudden cessation may lead to rebound effects or worsening of symptoms.

Side Effects

Common Side Effects

Common side effects of Dolo D Tablet may include:

• Headache
• Dizziness
• Diarrhea
• Nausea
• Vomiting
• Flatulence
• Abdominal pain These side effects are usually mild and temporary, resolving on their own without the need for medical intervention.

Serious Side Effects

More serious side effects that require immediate medical attention include:

• Severe allergic reactions (anaphylaxis)
• Stevens-Johnson syndrome
• Toxic epidermal necrolysis
• QT prolongation
• Severe diarrhea (possibly due to Clostridioides difficile)
• Liver dysfunction
• Vitamin B12 deficiency (with long-term use)

Warnings and Precautions

• Pregnancy & Breastfeeding: Dolo D Tablet should be used during pregnancy only if clearly needed, as the safety of Domperidone and Pantoprazole in pregnant women has not been well established. For breastfeeding mothers, Domperidone is known to influence prolactin levels, which may affect milk production, but the clinical significance of this effect is not well understood. Therefore, caution is advised.
• Driving & Heavy Machinery: Patients taking Dolo D Tablet should be cautious when driving or operating heavy machinery, as dizziness and other central nervous system effects may occur.
• Alcohol Interaction: The interaction between alcohol and Dolo D Tablet is not well-studied. However, it is generally recommended to avoid or limit alcohol consumption to minimize potential gastrointestinal irritation and other adverse effects.
• Kidney & Liver Caution: Patients with severe renal impairment or liver disease should use Dolo D Tablet with caution, as the metabolism and excretion of its components may be affected, potentially leading to increased drug levels and toxicity.

Contraindications

Dolo D Tablet is contraindicated in patients with:

• Known hypersensitivity to Domperidone, Pantoprazole, or any component of the formulation
• Prolactinoma (Domperidone may stimulate the production of prolactin)
• Gastrointestinal bleeding, mechanical obstruction, or perforation
• Severe hepatic impairment

Drug Interactions

Dolo D Tablet may interact with several medications, including:

• Antifungals (e.g., ketoconazole, itraconazole) that may increase the levels of Pantoprazole
• Warfarin, whose effects may be enhanced by Pantoprazole, leading to increased risk of bleeding
• Medications that inhibit or induce the cytochrome P450 system, potentially affecting the metabolism of Domperidone and Pantoprazole
• Antibiotics, such as erythromycin, which may interact with Domperidone

Frequently Asked Questions

1. Can I take Dolo D Tablet for a headache?

   • No, Dolo D Tablet is specifically designed to treat gastrointestinal issues such as acid reflux and peptic ulcers. For headaches, you should consult your doctor for appropriate medication.

2. Is Dolo D Tablet an antibiotic?

   • No, Dolo D Tablet is not an antibiotic. It is a combination of a gastroprokinetic agent (Domperidone) and a proton pump inhibitor (Pantoprazole), used to treat conditions like acid reflux and peptic ulcers.

3. How long does it take for Dolo D Tablet to start working?

   • The onset of action of Dolo D Tablet can vary depending on the condition being treated. For some symptoms like heartburn, relief may be felt within a few days, while the full effects of healing ulcers may take several weeks.

4. Can I take Dolo D Tablet with other medications?

   • It is essential to inform your doctor about all the medications you are currently taking, including over-the-counter drugs and supplements, to avoid potential drug interactions.

5. Is Dolo D Tablet safe for long-term use?

   • While Dolo D Tablet can be used for an extended period under medical supervision, long-term use of proton pump inhibitors like Pantoprazole has been associated with an increased risk of osteoporosis-related fractures and vitamin B12 deficiency. Regular monitoring by a healthcare provider is recommended.