Have you heard of Bremelanotide or PT-141? Does it work for premenopausal women only? Or is this amazing new drug a new ...

you-won39t-believe-the-hidden-benefits-of-pt-141-for-sexual-desire

You Won&#39;t Believe the Hidden Benefits of PT-141 for Sexual Desire

have you guys heard of Bree melanotide or pt141 well I'm Dr Rena Malik urologist and pelvic surgeon and today I'm going to explain to you all about how green melanotide can be used to increase libido and potentially even help with erections free melanotide is a melanocyte stimulating hormone analog meaning that it works just like msh and it's been studied for both men and women and is FDA approved for women with hypoactive sexual desire disorder similar to that little pink pill I talked about in my last video however this is used as needed one hour to 45 minutes before sex so an hour before you want to want and interestingly it works on the brain so let's take it back the melanocortin system is a group of substances all of these things together control several different things like how much we eat how we feel pain the color of our skin and even our sexual activity so very simply melanocortons are excited Tory signals that reach certain areas of our brain like the cortex and Thalamus which then cause increased sexual receptiveness meaning they feel more desire for sex when they are stimulated and so scientists initially studied this melanocyte stimulating hormone in animals and what they found was that led to increased sexual receptiveness and it led to two interesting findings one is that there was an increase of nitric oxide in the genitals and if you're new here I'll tell you that nitric oxide is the ignition for erections and sexual activity it also led to dilation or opening up of blood vessels so that more blood flow was able to get to the genitals and this then led to the development of Brie melanotide also known as pt-141 and so as I mentioned this has been approved for premenopausal women and when they looked at women taking this medication under functional MRI studies which means they could watch the brain change or light up different areas when the patient took brimalanotide they found that certain areas of the brain that were usually decrease in activation in patients who had hypoactive sexual desire disorder were activated meaning that they were more easily aroused when approached with erotic stimuli it also decreased activation in certain areas allowing there to be less self-consciousness and they increase some areas of connectivity in the brain which may lead to again greater sexual arousal so what they found is that in these women they had increased sexual desire for up to 24 hours after taking the medication they noticed that the increase in desire was seen at about 2.5 times more women than those getting a placebo injection or injection without any active ingredient in it and interestingly they also found that women had a little bit of decreased hunger when taking this medication now this was in a small study looking at the brain but in larger studies in multiple clinical trials they saw similar effects being 2.6 times increase in sexual desire in women taking bremelanotide now it's recommended that you take it only once within 24 hours and no more than 8 times a month if you're gonna take it you need to take it with birth control because the effects on a growing fetus are yet unknown it is contraindicated in anyone who has uncontrolled high blood pressure or heart disease and the most common side effect is nausea which occurs in up to 40 of women who take it but this can be treated by taking antiemetics or medication to decrease nausea at the time of administration also that nausea tends to decrease after the first time you take it other common side effects were flushing at about 20 percent headaches and about 11 vomiting in five percent and focal hyperpigmentation in less than one percent of patients and that meant that they were a little bit more tanned or darker in areas like the face the gums and the axilla so this is a great option for women but what about men well Bree melanotide has been studied in a subset of men for the purposes of low libido and erectile dysfunction the number of patients that have been looked at have ranged anywhere from 19 patients to up to 342 patients and in these small studies these men took premarital either as a nasal spray or as an injection and what they found was that Brie melanotide did increase low desire it also increased the rigidity of the erection the duration of the erection and overall satisfaction with sexual intercourse the side effects most commonly were nausea and flushing in the largest study 342 married men were recruited who had taken sildenafil but didn't respond and they were given either 10 milligrams of Brie melanotide as a nasal spray or they were given a placebo and they were told to use it 45 minutes to two hours before intercourse and they had to try it for at least 16 uses over the course of the study period they described a positive clinical response's ability to maintain an erection and satisfaction with intercourse and they saw a positive response in 33 percent of men who took the medication versus eight percent of men who took the placebo and so this sounds great do we have a new option for erectile dysfunction or even low desire for men not yet so this is still in clinical studies for men it has not gone through the rigorous trials it needs to go through to become FDA approved as a medication for low desire or erectile dysfunction for men however it is given off label from what I've understand anecdotally is taking this medication gives you a very strong desire for intercourse which can be very uncomfortable if intercourse is not on the table also it is associated with some nausea and usually after using the medication you can feel as if you've got a cold or some significant fatigue after it wears off generally speaking if you've got really bad high blood pressure or really bad heart disease I don't recommend trying this and if you really want to try this I suggest you see a urologist or other healthcare provider who is expert in sexual medicine so that you can be overseen and make sure that you're doing well on this medication you're not having any adverse effects and that if you do have a problem that someone else there to help take care of you alright I hope this answers some of your questions as always you want to take care of yourself because you are worth it [Music] thank you [Music]

Dr.

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